![]() The Encore GX offers numerous standard driver-assistance technologies a rearview camera mirror and 360-degree camera system will be optional. We fit five carry-on suitcases behind the GX's rear seats and 16 with the rear seats folded, which is only a few less than the slightly larger Cadillac XT4. The Encore GX's front-passenger seat folds flat to aid in loading longer items, and we expect the rear cargo area to be more generous than the smaller Encore. Buick's positioning in the market straddles the line between luxury and mainstream, so it's better equipped than base-level versions of rivals such as the Nissan Kicks and Subaru Crosstrek, but it doesn't provide the same level of fit and finish as the Audi, BMW, and Volvo. The Encore GX's quiet cabin features leather upholstery, heated seats, and more passenger space than the smaller Encore. For more information about the Encore GX's fuel economy, visit the EPA's website. However, on our 200-mile highway fuel-economy test route, the Encore GX with the larger engine, all-wheel drive, and nine-speed automatic managed 30 mpg, beating the EPA's estimate by 1 mpg. Going with the smaller 1.2-liter mill drops that figure to 30 mpg, and going with the 1.3-liter with all-wheel drive and the nine-speed automatic drops it further to 29 mpg. With front-wheel drive and the CVT, the turbocharged 1.3-liter is said to achieve up to 32 mpg highway. Ironically, the larger of the two three-cylinder engines receives the highest fuel-economy ratings from the EPA. Tested: 2020 Encore GX Works Well, Bores Us.The Buick's ride is also agreeably smooth and controlled, but it doesn't offer any handling thrills. On the road, the Encore GX feels peppier than its acceleration results suggest, particularly around town where the small turbo engine delivers good low-end grunt. The Encore GX's luxury-branded rivals-the Audi Q3, the BMW X1, and the Volvo XC40-offer more powerful engines and far quicker acceleration times. At our test track, the Encore GX with all-wheel drive, the nine-speed automatic, and the larger 1.3-liter four-cylinder required a slothful 9.3 seconds to reach 60 mph. Likewise, the slightly bigger engine exclusively uses a nine-speed automatic transmission. While the more powerful engine is available on fancier front-drive models, it's included on every Encore GX with all-wheel drive. The former pairs with a continuously variable automatic transmission (CVT) and front-wheel drive. The base version is a 1.2-liter that develops 137 horsepower followed by an optional 1.3-liter that makes 155 ponies. The Encore GX is powered by two turbocharged three-cylinder engines. ![]() ![]() All-wheel drive is optional and adds $2000 to the price of any Encore GX. The Experience Buick package adds navigation and a power sunroof. It comes with handsome 18-inch wheels, roof-rack side rails, an eight-way power adjustable driver's seat, heated front seats, a rear-seat center armrest, remote start, and dual-zone automatic climate control. The best value in the lineup appears to be the midrange Select model. The price of the 2022 Buick Encore GX starts at $27,095 and goes up to $31,620 depending on the trim and options. Otherwise, the junior Buick SUV rolls into 2022 with no changes. What's New for 2022?Ī quartet of new colors joins the Encore GX's palette for 2022: Cinnabar Metallic, Sapphire Metallic, Rosewood Metallic, and Sunset Glow Metallic. Its cabin is roomy and well-equipped, which helps it against those non-luxury crossovers, but it doesn't quite have the panache of the German utes. Depending on how it's equipped, the Encore GX either competes with mainstream subcompact SUVs such as the Mazda CX-30 and the Hyundai Kona or small luxury crossovers such as the BMW X1 and the Mercedes-Benz GLA-class. Handling is stable, and the ride is smooth. Acceleration is adequate, but neither of them will satisfy lead-footed drivers. The Encore GX comes with your choice of either a turbocharged 1.2-liter or turbocharged 1.3-liter three-cylinder engine. If the regular Encore is too small for you, consider stepping up to the 2022 Buick Encore GX, which is both slightly larger and more modern.
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![]() He was let go, quite unexpectedly and after being told how “valuable” he was, from a job that he truly loved and looked forward to every day. We have such an opportunity each and every day to pick our head up from whatever we might think is “critical” in the moment and focus our attention on something “sweeter,” or a friend who needs us, or something that we enjoy.Ī client of mine is out of work right now. How he “spoke sweeter” and “became a friend a friend would like to have.” These are the opportunities that are available to us no matter what else is happening in our lives. But one of the other lines in the song talks about how he “gave forgiveness” he’d been denying. It’s not possible for everyone to drop what they are doing and go skydiving or bull riding. Only when a person finds that their life might be over do they stop caring or worrying about the bills to be paid, the retirement account to be funded and the next week’s commitments. Why does it take a significant life event to break our hold on what we “have to do” and get us to focus on what we’d “love to do”? I know for many people it’s the realities – we have to make a living, we have commitments, we can’t abandon the responsibilities staring us in the face each day. He says that he hopes everyone gets the chance to “live like you were dyin’.” ![]() He sings about a man who is diagnosed with a terminal illness and uses the opportunity to do things he would never have done – go skydiving, go rocky mountain climbing, and sit on a raging bull for 2.7 seconds. ![]() For those readers who dislike country music, it probably gets old that I find so much of my material here, but this line from one of Tim McGraw’s biggest songs always gets to me. ![]() The other 10,000 avatars publicly launched 2 days later!īut do you know what the coolest thing about the collection is? It’s that this collection is the product of Takashi Murakami’s collab with RTFKT! He actually designed the different Clone X elements. 10,000 avatars were available in a 2-day pre-sale for existing RTFKT NFT owners. Anyway, owners of these avatars can actually use them as skin in the Metaverse and so on. They’re much more than PFPs, although these on their own could be a win. But if you wanna read about Clone X – An OverviewĬlone X is an NFT collection of 20,000 algorithmically generated 3D avatars. For now, we’re gonna focus on one of the studio’s best NFT works: Clone X. In fact, Nike was so impressed with RTFKT’s work that they ended up acquiring the brand! However, we’ll get back to this later on. For example, who doesn’t know who Jeff Staples and Takashi Murakami are today? Exactly. Next up, they scored some lit a$$ collabs with big names in pop culture. Their virtual sneakers and apparel certainly caused a wave of hype! First off, they were among the first to bridge the gap between physical and virtual worlds. We’d also like to mention that RTFKT managed to make its name in the virtual world using many methods. ![]() RTFKT studios is a digital NFT studio that launched cool sneakers which caught lots of attention. But before we launch into our story, make sure you check out the previous collections we covered:īefore the Clones, What Is RTFKT Studios?Īlthough we already covered RTFKT here, a recap can never hurt. And we’re gonna discuss all the elements that made Clone X as hot as it is today. Clone X kinda set the bar high for all types of NFT artwork, no jokes! Anyway, good art isn’t the only reason this collection is a success. We’re honored to work in partnership with RTFKT to help them bring their vision forward,” CAA President Jim Burtson said.Today, we’re gonna discuss one of the coolest and most eye-pleasing NFT collections out there. “Everything RTFKT does embodies creativity, and like CAA, they value serving their community above all else. Working with CAA, RTFKT will also create a series of webinars and other educational programming for other crypto- and 3D-focused artists, with sessions taking place on platforms like Discord and Twitter Spaces. “Being able to work with such a world-class team and explore new mediums for our IPs and creativity, such as TV, film and define what the future of interactive storytelling is a dream come true.” “We’ve always built our brand to inspire the next generation of creators, accelerating a future where talent and creatives can merge cultures and technology in new ways,” Pagotto said in a statement. Other partnerships have included the luxury suitcase brand Rimowa, the designer Jeff Staple and the perfume and cologne company Byredo. Terrence Howard Sues CAA Over 'Empire' Salary With Nike, RTFKT has released four digital collections, including for a pair of smart sneakers known as Cryptokicks iRL and a collection of Nike Air Force 1. Major projects have included CloneX, an NFT collection created with the designer Takashi Murakami that has generated more than $500 million in secondary sales to date, according to CAA. In early 2021, the company raised $8 million in seed funding, led by Andreessen Horowitz, at a valuation of $33.3 million before getting acquired by Nike at the end of the year for an undisclosed sum. The studio, pronounced “artifact,” was created in 2020 by Benoit Pagotto, Chris Le and Steven Vasilev amid the frenzy around NFTs, digital collectibles and the metaverse. RTFKT, the design studio best known for creating virtual and digital sneakers, has signed with CAA to explore film and TV projects based on the company’s IP. ![]() Step 1: Go to DiffusionBee’s download page and download the installer for MacOS – Apple Silicon. 6 conda activate The Automatic1111 Stable Diffusion WebUI has over 100k stars on GitHub and more than 480 people have so far contributed to improving the WebUI. So the magic is in the potential of having a better alternative to A1111. You can jump to the video parts that You can use Automatic1111 stable diffusion using an amd card. The total number of parameters of the SDXL model is 6. Refresh your model list or restart the Stable Diffusion Web UI. Thanks to the passionate community, most new features come to this free Stable Diffusion GUI ComfyUI vs AUTOMATIC1111. ![]() You can even Apr 26 Are you a Mac user who’s been struggling to run Stable Diffusion on your computer locally without an external GPU? If so, you may have heard of Vlad, a I’ve been doing some extensive tests between diffuser’s stable diffusion and AUTOMATIC1111’s and NMKD-SD-GUI implementations (which both wrap the If you’re someone who wants to use Stable Diffusion to generate AI art, then Automatic1111 is the best and easiest interface out there to get started. bat to update web UI to the latest version, wait till Best NVIDIA Windows DRIVERS FOR Stable Diffusion 20xx, 30xx, 40xx AUTOMATIC1111 / stable-diffusion-webui Public. If you put in a word it has not seen before, it will be broken up into 2 or more sub-words until it knows what it is. Its image compostion capabilities allow you to assign different prompts and weights, even using different models, to specific areas of an image. Using an Olive-optimized version of the Stable Diffusion text-to-image generator with the popular Automatic1111 distribution, performance is improved over 2x with the new driver. Midjourney’s models are limited in comparisons. 1-768 looks way worse at the same steps, sampler, etc. ![]() Select the custom model from the Stable Diffusion checkpoint input field. We tested 45 different GPUs in total - everything that has New VAE vs old VAE and how to use/update it. NVIDIA's PR statement is totally misleading. NVIDIA's PR Stable studio vs automatic1111, 0 and 2. ![]() ![]() In comparison to stainless steel blades, carbon steel blades stay sharper as long as you take good care of them by hand-washing after each use. It has a super sharp carbon steel blade, feels light in the hand, and works quickly on large vegetables. The Details: Measures 0.75 x 1.25 x 7.25 inches stainless steel blade, manual operationĭon't let the size or price point fool you: The Kuhn Rikon Original Swiss Peeler is a solid option for many reasons. Best of all, you can easily clean it in the dishwasher after each use. Like many other OXO products, this peeler has an ergonomic handle for a comfortable, secure grip, plus it has a hole at the end of the handle for wall storage. This model is the newer version of the original OXO Good Grips Swivel Peeler, so it has all the good parts of the first product yet features a sharper blade for smoother cuts. With a sturdy stainless steel blade and sharp eye remover that can easily scoop out potato eyes and other blemishes, it's no wonder why this peeler stands out from the rest. Īs our best overall pick, this OXO peeler can tackle hearty veggies, like carrots and potatoes, just as well as it can create delicate lemon rinds for garnishing drinks or ribbons of your favorite squash. Most Versatile: Deiss Pro Dual Julienne Peeler & Vegetable PeelerĪlso available at Williams Sonoma and Bed Bath & Beyond.Most Ergonomic: Spring Chef Premium Swivel Vegetable Peeler. ![]() Best Electric: Starfrit Rotato Express 2.0 Peeler.Best for Large Vegetables: OXO Large Y Prep Peeler.Best Budget: Kuhn Rikon Original Swiss Peeler.Best Overall: OXO Good Grips Pro Swivel Peeler.Keep scrolling to see our full list of the best vegetable peelers of 2022. We landed on the OXO Good Grips Pro Swivel Peeler as our winner because of its comfortable, nonslip handle and razor-sharp steel blade. To help you find the right vegetable peeler for your needs, we rounded up the top models on the market after analyzing their style, cost, and features. They come in different shapes and feature different blade materials, but, ultimately, they all serve the same purpose - removing the outer layer of fruits and veggies. Some require manual effort, while others work at the press of a button. The right vegetable peeler can make quick work of a bag of potatoes before mashing, especially if they have added features like a potato eye remover or a comfortable grip handle.Īlthough it seems like a basic gadget, there are actually many different types of peelers to choose from. While using a knife is always an option, vegetable peelers are a much safer and more effective option. Peeling veggies can be a daunting task if you don't have the right tool to get the job done. ![]() ![]() And for sine and cosine there is also the link with geometry. The same function appears again and again in a range of otherwise very different real world systems, even ones governed by (seemingly) quite different physical or other laws. This is a very analogous phenomenon to that of exponential growth and decay. Sine and cosine functions describe simple harmonic motion ( ), which is everywhere: it describes (approximately) the motion of a pendulum or spring, the flow of alternating current ( ), the length of a day ( ) - essentially any situation where a system stays near (but not exactly at) an equilibrium position. ![]() In other words, it’s at least clear that there is an explanation, even if you don’t have it at your fingertips. And even though most people end up memorizing the quadratic formula, it is at least derivable using a simple completion of the square. Although it’s not obvious that everyone needs higher level algebra in their daily lives (although they most definitely do need to solve systems of linear equations), it’s still more defensible to teach them to factor quadratic polynomials than it is to introduce arctan. We’d be simply replacing trig with some other crappy topic choice. Moreover, he suggested, if we remove trig, then meeting people at an airport would just elicit some other reason for hating math. Namely, that we have really no reason to teach high school kids any given thing, so we just choose a bunch of things kind of at random. When I mentioned my hatred of trigonometry to my husband, he countered with an argument that wasn’t mentioned so far. Nobody mentioned that ship captains needed trig, but again we have GPS now.Again, I’m willing to bet they also know about the complex plane. Someone mentioned that they use trig functions every day at work in the physical sciences.We could end the lesson with a historical remark along the lines of, by the way these functions have names, they’re called the sine and cosine functions, and you’ll learn more about them when you learn about the complex plane and Fourier Analysis. Even just talking about an ant walking around the unit circle would be sufficient, especially if we asked for the x- and y- coordinates of the ant at a given time. While that’s true, we don’t need to go deeply into the subject – never mind double angle formulas – to explain that. Someone mentioned that trig functions are great examples of periodic functions.Someone mentioned it’s needed in “shop class.” But then they went on to explain the shop classes no longer exist.A few people stood up for trig in the comments. I wrote a post about statistics and algebra teaching in high schools a while ago, and in that post I suggested chucking trig from the curriculum. Next, this isn’t the first time I have pooped on trig. It helped, but even then I had memorized it, and it wasn’t until college that I understood it. In fact my mom did me the favor of explaining the above formula to me when I was in high school so I could avoid all the memorization. Understanding this formula, the Fourier Analyst is equipped to work with trig functions without all the mystery, and absolutely no memorization. ![]() But by the time you’re working with Fourier Analysis, you have more mathematical technology, and in particular you know the magic formula which makes all mysterious double and half angle formulas super easy, namely Euler’s Formula: A few comments before you decide I’m being unfair.įirst, yes, trigonometric functions are needed in Fourier Analysis, which is hugely important nowadays for the sake of music files and information compression. It’s almost a case study in how to make someone feel like math is meant to be mysterious. It’s never clear why you’re learning it, except for the possibility of later memorizing the integrals and derivatives of said functions. It’s a terribly unmotivated subject, and as a student you are expected to memorize double angle formulas with no proofs. When I ask why, they often suggest it was trigonometry that killed any interest they might have had for the subject. Then they pretty much always tell me how much they hate math. When they ask me what I do for a living, I often say I’m a mathematician. I’m a friendly, talkative kind of person (at least when I haven’t slept in a wet tent for two nights straight). I meet a lot of people, at airports and music festivals. ![]() The insert tips were parallel to the tooth axis and the working strokes ran ![]() 6A, Hu-Friedy, Leimen, Germany) after instrumentingĮach tooth. The curette was re-sharpened with a sharpening stone With the hand curette the working strokes ran from apical to coronal direction, parallel In Group C teeth were scaled with an EMS piezoelectric ultrasonic device with prototype USA) In Group B Cavitron TM FSI - SLI TM ultrasonic device withįocused spray slimline inserts (Dentsply International Inc., York, PA, USA) were used. Universal hand curette (Hu Friedy Gracey After Five Vision curette Hu Friedy, Chicago, In Group A all teeth were carefully scaled with a new The teeth were to be instrumented with hand and ultrasonic instruments Each tooth was positioned horizontally on a dental stone block of 1 Subgingival calculus were divided into 3 experimental groups using a randomized rank Thirty periodontally compromised extracted human teeth with supragingival and The efficacy of manual, magnetostrictive and piezoelectric ultrasonic instruments. Thus, the present study was conducted to comparatively evaluate Little has been published about the piezoelectric Investigated only magnetostrictive ultrasonic scalers 6, 7, 18. Ultrasonic scaler removed the least root surface substance. This concern was subsequently put to rest by studies such as that of Initially, ultrasonic scalers were employed with apprehension because of suspected root Of the root planed surface can be performed only by means of scanning electron Stereomicroscope to evaluate the residual calculus after extraction of the root planed Immediately after treatment in order to observe directly the cleanliness and surfaceĬharacteristics of the root planed surfaces. Healing around the treated teeth can be evaluated, or the teeth may be extracted The efficacy of root planing procedures can be studied in two different ways. Instruments is impossible or rare even when a surgical approach is used 3, 19. Complete removal of subgingival calculus with hand or ultrasonic The treatment of chronic periodontitis 20. Studies do not indicate a difference between ultrasonic/sonic and manual debridement in Objective can be achieved with hand scalers and curettes or ultrasonic scaling ![]() One of the objectives of periodontal therapy is the reduction of bacterial deposits and ![]() (Image credit: Apple) How to fix macOS Big Sur install problems There are several possible reasons why the macOS is having issues installing. If you are having this issue, try starting your Mac in Safe Mode (hold down Shift on the keyboard while it boots), then try downloading and installing macOS Big Sur again. In addition, another of the most common macOS 11 Big Sur problems that's received a lot of complaints has been around the download stopping, and the system throwing up a "gateway timed out" or "bad gateway" error. How to fix "gateway timed out" error when downloading macOS Big Sur You may be able to restart the download from there.įinally, try logging out of the Store to see if that restarts the download. Delete them, then reboot your Mac and try to download macOS Big Sur again.Īnd, if that doesn’t work, try opening the App Store and clicking ‘View My Account’ to see if there is anything in the ‘Unfinished Downloads’ section. If you’re still having problems downloading macOS Big Sur, try to find the partially-downloaded macOS 11 files and a file named ‘Install macOS 11’ on your hard drive. It may also be worth switching from a Wi-Fi connection to an Ethernet cable, to ensure your internet connection is as reliable as possible. ![]() If you're running low, open up the Apple menu, click 'About this Mac' then go to Storage > Manage and free up some disk space there. To make sure you do, open up the Apple menu and click on 'About This Mac.' Select 'Storage' then check to make sure you have enough space on your hard drive. Typically, a macOS download fails if you do not have enough storage space available on your Mac. If it has a green dot, then there's no issue, but other colors suggest there's a problem with Apple delivering the update.Īs you can see from the screenshot above, there had been issues with the software update at the time of writing, which have since been resolved.Īnother reason could be that you simply do not have enough space on your computer. There should be a section labelled 'macOS Software Update'. You can also check the live status of the Apple Server to make sure everything is alright on Apple's end. If you think this is the case, try again later on a non-peak time to see if the download works then. It may be because a lot of people are trying to download macOS Big Sur at the same time. There are a few reasons why you may encounter this issue. That content can’t be downloaded at this time. Installation requires downloading important content. A few get the following error message: “Installation of macOS could not continue. Others, on the other hand, are seeing "The network connection was lost" error messages when they try to download macOS Big Sur. One of the most common macOS 11 Big Sur problems that people have encountered is that macOS 11 fails to download, with some users seeing an error message that says "Installation failed." How to fix macOS Big Sur download problems For those of you sticking with us, let's take a look at the most common macOS 11 Big Sur Problems and exactly how to solve them. Or, if you’re ready to take the leap to the next OS, check out how to download macOS 12 Monterey. If you haven’t grabbed Big Sur yet, take a look at our how to download and install macOS 11 Big Sur guide. ![]() Smile Now Cry Later Shoulder Ink Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram 9. Smile Now Cry Later Neck Tattoos Source: via Instagram Source: via Instagram Source: via Instagram 8. Theater Mask Tragedy Comedy Tattoos Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram 7. Smile Now Cry Later Leg Tattoos Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram 6. ![]() Happy masks are called Thaia, while sad masks are called Melpomene. The masks portray feelings of happiness and sadness. It is most times referred to as a gang tattoo. Smile Now Cry Later Tattoos for the Forearm Source: via Instagram Source: via Instagram Source: via Instagram 5. The laugh now cry later tattoo design shows two faces or two theater masks representing different emotions. Feminine Smile Now Cry Later Tattoo Ideas Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram 4. Clown Smile Now, Cry Later Tattoo Designs Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram 3. Chicano Smile Now, Cry Late Tattoo Ideas Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram Source: via Instagram 2. It has since become a popular theme in various forms of art, including tattoos, where it represents the acceptance and understanding of life's ups and downs. Smile now cry later tshirt, cholo tshirts. The concept of 'Laugh Now Cry Later' symbolizes the duality of emotions and the idea that one should embrace both joy and sorrow in life. The following collection of smile now, cry later designs showcase the best in chicano tattooing and symbolic body art dedicated to these theater masks. cry later laugh drawings gangster clown smile sad happy tattoo face joker clipart masks clipartmag. Smile now cry later represents the need to hide weakness from enemies on the street and informs many of the designs utilized in Chicano tattooing.įor others collectors (I have the theater masks tattooed on my right shoulder blade in black and gray), tragedy/comedy is a reminder that life is full of ups and downs, and keeping an outwardly even keel is a good way of dealing with different emotions. See more ideas about latest tattoos, tattoos, sleeve tattoos. When Freddy Negrete first inked a “smile now, cry later” tattoo dedicated to the hard faces Mexican Americans had to wear in difficult circumstances, it is doubtful he knew how profound the impact would be. Explore Tattoo Jasons board 'smile now cry later tattoos', followed by 152 people on Pinterest. Alongside the words “smile now, cry later,” the smiling and weeping pair of theater masks are common design examples of the quintessentially Chicano tattoo. Although TSC1 and TSC2 themselves are tumor suppressors, the TSC complex is often functionally inactivated in cancer through mutations in upstream oncogenes and tumor suppressors, thus providing the most frequent route of mTORC1 activation in cancer. 4 The tuberous sclerosis complex (TSC) protein complex, comprising TSC1, TSC2 and TBC1D7, is an essential negative regulator of mTORC1. ![]() 1, 2, 3 The activation of mTORC1 drives growth-promoting anabolic processes, including a coordinated increase in the synthesis of proteins, lipids and nucleotides. The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a critical convergence point for the most common oncogenic signals, leading to aberrant, growth factor-independent activation of mTORC1 signaling in the majority of human cancers. These data expose a therapeutic vulnerability in regulation of the apoptotic machinery downstream of mTORC1 that promotes a cytotoxic response to rapamycin. The BCL-2/BCL-X L inhibitor ABT-263 synergizes with rapamycin to induce apoptosis in TSC-deficient cells and in a mouse tumor model of TSC, resulting in a more complete and durable response. In TSC2-deficient cells and tumors, we find that mTORC1 inhibitors shift cellular dependence from MCL-1 to BCL-2 and BCL-X L for survival, thereby altering susceptibility to BH3 mimetics that target specific pro-survival BCL-2 proteins. We sought to determine the effects of mTORC1 on the core regulators of intrinsic apoptosis. Clinically approved mTORC1 inhibitors, such as rapamycin, elicit a cytostatic effect that fails to eliminate tumors and is rapidly reversible. It consists of 1 video and 6 images.MTORC1 is aberrantly activated in cancer and in the genetic tumor syndrome tuberous sclerosis complex (TSC), which is caused by loss-of-function mutations in the TSC complex, a negative regulator of mTORC1. The piece was submitted to the medium: Design (Pharmaceutical) within the entry type: Direct-to-Consumer - Unbranded and the category: Digital / Mobile. This 2023 Clio Health Gold winning entry titled 'Eyedar' was entered for Horizon Therapeutics by Area 23, an IPG Health Company, New York. ![]() Justine Pujo / Area 23, an IPG Health Companyīill Hanff / Area 23, an IPG Health Companyįrank LaPort / Area 23, an IPG Health Companyīrian Binns / Area 23, an IPG Health Company Sam Astigarraga / Area 23, an IPG Health CompanyĮVP, Group Director, Integrated Production Jessica Haselkorn / Area 23, an IPG Health CompanyĪnna Lopez / Area 23, an IPG Health Company Lauren Dellaquila / Area 23, an IPG Health Company Jeff Halpin / Area 23, an IPG Health Company Jake Moon / Area 23, an IPG Health Company Sydney McElwee / Area 23, an IPG Health Company ![]() Stefan Hanley / Area 23, an IPG Health Company ![]() Rosie Mossey / Area 23, an IPG Health Companyĭenise Bankson / Area 23, an IPG Health Companyĭane Lund / Area 23, an IPG Health CompanyĬaitlin Workman / Area 23, an IPG Health Company Jason Graff / AREA 23, an IPG Health Companyĭavid Adler / AREA 23, an IPG Health Companyįranklin Williams / Area 23, an IPG Health CompanyĪaron Stack / Area 23, an IPG Health CompanyĮduardo Tavares / Area 23, an IPG Health Company Tim Hawkey / AREA 23, an IPG Health Company |
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